TY - JOUR
KW - Breast cancer
KW - Immunotherapy
KW - organoid
KW - Tumor Microenvironment
AU - Dandan Guan
AU - Xiaozhen Liu
AU - Qingyang Shi
AU - Bangjie He
AU - Chaopeng Zheng
AU - Xuli Meng
AB - Immunotherapy is garnering increasing attention as a therapeutic strategy for breast cancer (BC); however, the application of precise immunotherapy in BC has not been fully studied. Further studies on BC immunotherapy have a growing demand for preclinical models that reliably recapitulate the composition and function of the tumor microenvironment (TME) of BC. However, the classic two-dimensional in vitro and animal in vivo models inadequately recapitulate the intricate TME of the original tumor. Organoid models which allow the regular culture of primitive human tumor tissue are increasingly reported that they can incorporate immune components. Therefore, organoid platforms can be used to replicate the BC–TME to achieve the immunotherapeutic reaction modeling and facilitate relevant preclinical trial. In this study, we have investigated different organoid culture methods for BC–TME modeling and their applications for precision immunotherapy in BC.
BT - World Journal of Surgical Oncology
DA - 2023-10-26
DO - 10.1186/s12957-023-03231-2
IS - 1
LA - en
N2 - Immunotherapy is garnering increasing attention as a therapeutic strategy for breast cancer (BC); however, the application of precise immunotherapy in BC has not been fully studied. Further studies on BC immunotherapy have a growing demand for preclinical models that reliably recapitulate the composition and function of the tumor microenvironment (TME) of BC. However, the classic two-dimensional in vitro and animal in vivo models inadequately recapitulate the intricate TME of the original tumor. Organoid models which allow the regular culture of primitive human tumor tissue are increasingly reported that they can incorporate immune components. Therefore, organoid platforms can be used to replicate the BC–TME to achieve the immunotherapeutic reaction modeling and facilitate relevant preclinical trial. In this study, we have investigated different organoid culture methods for BC–TME modeling and their applications for precision immunotherapy in BC.
PY - 2023
EP - 343
T2 - World Journal of Surgical Oncology
TI - Breast cancer organoids and their applications for precision cancer immunotherapy
UR - https://doi.org/10.1186/s12957-023-03231-2
VL - 21
Y2 - 2026-06-03
SN - 1477-7819
ER -