TY - JOUR
KW - branching morphogenesis
KW - involution
KW - Lactation
KW - Mammary gland
KW - organoids
AU - Laurianne Temime
AU - Lamia Djoual
AU - Aurelie Chiche
AU - Han Li
AB - Mammary organoids bridge the gap between reductionist 2D systems and in vivo models by recapitulating bilayered epithelial architecture, branching, hormone responsiveness, and, in advanced platforms, functional readouts of lactation. This review synthesizes organoid models across the reproductive cycle, including branching morphogenesis, pregnancy-induced alveologenesis and milk secretion, and involution; it also surveys emerging directions, including embryonic/pluripotent and cross-species systems, as well as co-culture and organ-on-chip platforms that incorporate stromal, adipose, and immune elements. We outline priorities for building more complex, physiologically faithful ex vivo models that will enable mechanistic dissection of mammary development, yield comparative and translational insights, and create scalable platforms for perturbation and screening, advancing lactation research, breast cancer studies, and women's health in general.
BT - Biology of the Cell
DA - 2025
DO - 10.1111/boc.70048
IS - 12
LA - en
N2 - Mammary organoids bridge the gap between reductionist 2D systems and in vivo models by recapitulating bilayered epithelial architecture, branching, hormone responsiveness, and, in advanced platforms, functional readouts of lactation. This review synthesizes organoid models across the reproductive cycle, including branching morphogenesis, pregnancy-induced alveologenesis and milk secretion, and involution; it also surveys emerging directions, including embryonic/pluripotent and cross-species systems, as well as co-culture and organ-on-chip platforms that incorporate stromal, adipose, and immune elements. We outline priorities for building more complex, physiologically faithful ex vivo models that will enable mechanistic dissection of mammary development, yield comparative and translational insights, and create scalable platforms for perturbation and screening, advancing lactation research, breast cancer studies, and women's health in general.
PY - 2025
EP - e70048
T2 - Biology of the Cell
TI - Modeling Mammary Gland Development and Reproductive Cycles With Organoids
UR - https://onlinelibrary.wiley.com/doi/abs/10.1111/boc.70048
VL - 117
Y2 - 2026-06-03
SN - 1768-322X
ER -