TY - JOUR
AU - Gautam Mahajan
AU - Erin Doherty
AU - Tania To
AU - Arlene Sutherland
AU - Jennifer Grant
AU - Abidemi Junaid
AU - Aakanksha Gulati
AU - Nina LoGrande
AU - Zohreh Izadifar
AU - Sanjay Sharma Timilsina
AU - Viktor Horvath
AU - Roberto Plebani
AU - Michael France
AU - Indriati Hood-Pishchany
AU - Seth Rakoff-Nahoum
AU - Douglas S. Kwon
AU - Girija Goyal
AU - Rachelle Prantil-Baun
AU - Jacques Ravel
AU - Donald E. Ingber
AB - A dominance of non-iners Lactobacillus species in the vaginal microbiome is optimal and strongly associated with gynecological and obstetric health, while the presence of diverse obligate or facultative anaerobic bacteria and a paucity in Lactobacillus species, similar to communities found in bacterial vaginosis (BV), is considered non-optimal and associated with adverse health outcomes. Various therapeutic strategies are being explored to modulate the composition of the vaginal microbiome; however, there is no human model that faithfully reproduces the vaginal epithelial microenvironment for preclinical validation of potential therapeutics or testing hypotheses about vaginal epithelium-microbiome interactions.
BT - Microbiome
DA - 2022-11-26
DO - 10.1186/s40168-022-01400-1
IS - 1
LA - en
N2 - A dominance of non-iners Lactobacillus species in the vaginal microbiome is optimal and strongly associated with gynecological and obstetric health, while the presence of diverse obligate or facultative anaerobic bacteria and a paucity in Lactobacillus species, similar to communities found in bacterial vaginosis (BV), is considered non-optimal and associated with adverse health outcomes. Various therapeutic strategies are being explored to modulate the composition of the vaginal microbiome; however, there is no human model that faithfully reproduces the vaginal epithelial microenvironment for preclinical validation of potential therapeutics or testing hypotheses about vaginal epithelium-microbiome interactions.
PY - 2022
EP - 201
T2 - Microbiome
TI - Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip
UR - https://doi.org/10.1186/s40168-022-01400-1
VL - 10
Y2 - 2026-06-03
SN - 2049-2618
ER -