TY - JOUR
AU - Evelien De Clercq
AU - Isabelle Kalmar
AU - Daisy Vanrompay
AB - Chlamydia trachomatis is a Gram-negative obligate intracellular bacterial pathogen. It is the leading cause of bacterial sexually transmitted disease in the world, with more than 100 million new cases of genital tract infections with C. trachomatis occurring each year. Animal models are indispensable for the study of C. trachomatis infections and the development and evaluation of candidate vaccines. In this paper, the most commonly used animal models to study female genital tract infections with C. trachomatis will be reviewed, namely, the mouse, guinea pig, and nonhuman primate models. Additionally, we will focus on the more recently developed pig model.
BT - Infection and Immunity
DA - 2013-08-13
DO - 10.1128/iai.00357-13
IS - 9
N2 - Chlamydia trachomatis is a Gram-negative obligate intracellular bacterial pathogen. It is the leading cause of bacterial sexually transmitted disease in the world, with more than 100 million new cases of genital tract infections with C. trachomatis occurring each year. Animal models are indispensable for the study of C. trachomatis infections and the development and evaluation of candidate vaccines. In this paper, the most commonly used animal models to study female genital tract infections with C. trachomatis will be reviewed, namely, the mouse, guinea pig, and nonhuman primate models. Additionally, we will focus on the more recently developed pig model.
PY - 2013
SP - 3060
EP - 3067
T2 - Infection and Immunity
TI - Animal Models for Studying Female Genital Tract Infection with Chlamydia trachomatis
UR - https://journals.asm.org/doi/full/10.1128/iai.00357-13
VL - 81
Y2 - 2026-06-03
ER -