TY - JOUR
KW - cell culture
KW - evidence-based toxicology
KW - risk of bias
KW - user testing
AU - Gro H. Mathisen
AU - Gunn E. Vist
AU - Paul Whaley
AU - Richard A. White
AU - Trine Husøy
AU - Heather M. Ames
AU - Anna Beronius
AU - Emma Di Consiglio
AU - Ingrid Druwe
AU - Thomas Hartung
AU - Sebastian Hoffmann
AU - Carlijn R. Hooijmans
AU - Kyriaki Machera
AU - Pilar Prieto
AU - Joshua F. Robinson
AU - Erwin Roggen
AU - Andrew A. Rooney
AU - Nicolas Roth
AU - Eliana Spilioti
AU - Anastasia Spyropoulou
AU - Olga Tcheremenskaia
AU - Emanuela Testai
AU - Mathieu Vinken
AU - Camilla Svendsen
AB - A tool for evaluation of internal validity of in vitro studies called INVITES-IN is currently under development. The tool is designed specifically for cell culture studies. This protocol describes the testing of the performance of INVITES-IN. By performance, we mean the extent to which results of using INVITES-IN are the same for different users (consistency), the amount of time and cognitive effort it takes to apply INVITES-IN (assessor workload), the precision and potential for systematic error in results of applying INVITES-IN (accuracy), and how easy it is to use INVITES-IN (user experience). The participants in the user testing will be representative for the expected end-users of INVITES-IN which are persons preparing literature reviews including in vitro studies (e.g. in the context of chemical hazard and risk assessments or drug development). All end-users are expected to have experience with in vitro methods. Data collected from the performance testing will be used for further refinement and development of the release version of INVITES-IN.
BT - Evidence-Based Toxicology
DA - 2023-12-31
DO - 10.1080/2833373X.2023.2293289
IS - 1
N2 - A tool for evaluation of internal validity of in vitro studies called INVITES-IN is currently under development. The tool is designed specifically for cell culture studies. This protocol describes the testing of the performance of INVITES-IN. By performance, we mean the extent to which results of using INVITES-IN are the same for different users (consistency), the amount of time and cognitive effort it takes to apply INVITES-IN (assessor workload), the precision and potential for systematic error in results of applying INVITES-IN (accuracy), and how easy it is to use INVITES-IN (user experience). The participants in the user testing will be representative for the expected end-users of INVITES-IN which are persons preparing literature reviews including in vitro studies (e.g. in the context of chemical hazard and risk assessments or drug development). All end-users are expected to have experience with in vitro methods. Data collected from the performance testing will be used for further refinement and development of the release version of INVITES-IN.
PY - 2023
EP - 2293289
ST - Protocol
T2 - Evidence-Based Toxicology
TI - Protocol: Testing the Performance of INVITES-IN, A Tool for Assessing the Internal Validity of In Vitro Studies
UR - https://doi.org/10.1080/2833373X.2023.2293289
VL - 1
Y2 - 2026-05-07
SN - null
ER -