TY - JOUR
KW - 3D culture
KW - cell culture
KW - Differentiation
KW - Embryonic stem cells
KW - induced pluripotent stem cells
KW - microfluidics
KW - organ-on-a-chip
AU - Alexa Wnorowski
AU - Huaxiao Yang
AU - Joseph C. Wu
AB - In recent years, drug development costs have soared, primarily due to the failure of preclinical animal and cell culture models, which do not directly translate to human physiology. Organ-on-a-chip (OOC) is a burgeoning technology with the potential to revolutionize disease modeling, drug discovery, and toxicology research by strengthening the relevance of culture-based models while reducing costly animal studies. Although OOC models can incorporate a variety of tissue sources, the most robust and relevant OOC models going forward will include stem cells. In this review, we will highlight the benefits of stem cells as a tissue source while considering current limitations to their complete and effective implementation into OOC models.
BT - Advanced Drug Delivery Reviews
DA - 2019-02-01
DO - 10.1016/j.addr.2018.06.001
N2 - In recent years, drug development costs have soared, primarily due to the failure of preclinical animal and cell culture models, which do not directly translate to human physiology. Organ-on-a-chip (OOC) is a burgeoning technology with the potential to revolutionize disease modeling, drug discovery, and toxicology research by strengthening the relevance of culture-based models while reducing costly animal studies. Although OOC models can incorporate a variety of tissue sources, the most robust and relevant OOC models going forward will include stem cells. In this review, we will highlight the benefits of stem cells as a tissue source while considering current limitations to their complete and effective implementation into OOC models.
PY - 2019
SP - 3
EP - 11
T2 - Advanced Drug Delivery Reviews
TI - Progress, obstacles, and limitations in the use of stem cells in organ-on-a-chip models
UR - https://www.sciencedirect.com/science/article/pii/S0169409X18301327
VL - 140
Y2 - 2026-04-24
SN - 0169-409X
ER -