TY - JOUR
KW - Cell Line
KW - Clinical Trials as Topic
KW - Embryonic stem cells
KW - Humans
KW - induced pluripotent stem cells
KW - Pluripotent Stem Cells
KW - Publications
KW - stem cell research
KW - citation frequencies
KW - clinical trials
KW - hESC lines
KW - Human Embryonic Stem Cells
KW - human induced pluripotent stem cells
KW - human pluripotent stem cells
KW - impact
KW - Research
AU - Anke Guhr
AU - Sabine Kobold
AU - Stefanie Seltmann
AU - Andrea E. M. Seiler Wulczyn
AU - Andreas Kurtz
AU - Peter Löser
AB - The human pluripotent stem cell (hPSC) research landscape is rapidly evolving. To assess possible novel trends in hPSC usage, we analyzed experimental hPSC research published from 2014 to 2016 and compared our data with those of earlier periods. The number of papers describing experimental work involving hPSCs increased further with clear differences in the scientific impact of publications from different countries. Our results confirm the leading position of US-based hPSC research, although to a lesser degree than observed previously. Our data reveal that research into human induced pluripotent stem cells alone surpassed human embryonic stem cell (hESC) research by 2015 and rapidly grew after that. We also report on continuing and even slightly growing research activities in the hESC field as well as on a generally declining rate of the generation of new hESC lines. An increasing portion of new hESC lines represents disease-specific and clinical-grade cell lines. The previously noted usage of only a few early established hESC lines in the vast majority of scientific work is sustained. We also provide a comprehensive overview on clinical trials on the basis of hPSCs. We find that the vast majority of those trials are based on hESC-derived cell products that were generated from an only limited number of relatively old cell lines.
BT - Stem Cell Reports
DA - 2018-08-14
DO - 10.1016/j.stemcr.2018.06.012
IS - 2
LA - eng
N2 - The human pluripotent stem cell (hPSC) research landscape is rapidly evolving. To assess possible novel trends in hPSC usage, we analyzed experimental hPSC research published from 2014 to 2016 and compared our data with those of earlier periods. The number of papers describing experimental work involving hPSCs increased further with clear differences in the scientific impact of publications from different countries. Our results confirm the leading position of US-based hPSC research, although to a lesser degree than observed previously. Our data reveal that research into human induced pluripotent stem cells alone surpassed human embryonic stem cell (hESC) research by 2015 and rapidly grew after that. We also report on continuing and even slightly growing research activities in the hESC field as well as on a generally declining rate of the generation of new hESC lines. An increasing portion of new hESC lines represents disease-specific and clinical-grade cell lines. The previously noted usage of only a few early established hESC lines in the vast majority of scientific work is sustained. We also provide a comprehensive overview on clinical trials on the basis of hPSCs. We find that the vast majority of those trials are based on hESC-derived cell products that were generated from an only limited number of relatively old cell lines.
PY - 2018
SP - 485
EP - 496
ST - Recent Trends in Research with Human Pluripotent Stem Cells
T2 - Stem Cell Reports
TI - Recent Trends in Research with Human Pluripotent Stem Cells: Impact of Research and Use of Cell Lines in Experimental Research and Clinical Trials
VL - 11
SN - 2213-6711
ER -