TY - JOUR
KW - Animals
KW - Biomedical Research
KW - Disease Models, Animal
KW - Humans
KW - National Institutes of Health (U.S.)
KW - United States
KW - United States Food and Drug Administration
KW - Virology
KW - host-virus interactions
KW - model systems
KW - New approach methods (NAMs)
KW - translational virology
AU - Min Liu
AU - Jonathan G. Faris
AU - Amanda R. Panfil
AU - Cody J. Warren
AB - Animal models are a cornerstone of basic and translational virology research, widely used to study viral pathogenesis and evaluate vaccines and therapeutics. However, growing ethical and scientific concerns, alongside recent National Institutes of Health (NIH) and Food and Drug Administration (FDA) initiatives, are accelerating a shift toward non-animal, human-relevant alternatives. Advanced cell- and tissue-based systems now offer powerful platforms to model human disease. This Gem outlines emerging tools and highlights their promise for virology research in a rapidly evolving regulatory and technological landscape.
BT - Journal of Virology
DA - 2026-04-21
DO - 10.1128/jvi.01326-25
IS - 4
LA - eng
N2 - Animal models are a cornerstone of basic and translational virology research, widely used to study viral pathogenesis and evaluate vaccines and therapeutics. However, growing ethical and scientific concerns, alongside recent National Institutes of Health (NIH) and Food and Drug Administration (FDA) initiatives, are accelerating a shift toward non-animal, human-relevant alternatives. Advanced cell- and tissue-based systems now offer powerful platforms to model human disease. This Gem outlines emerging tools and highlights their promise for virology research in a rapidly evolving regulatory and technological landscape.
PY - 2026
EP - e0132625
T2 - Journal of Virology
TI - How new approach methods are reshaping virology research
VL - 100
SN - 1098-5514
ER -