TY - JOUR
KW - Computational biology and bioinformatics
KW - Engineering
AU - Rashmi Pandey
AU - Jennifer Lee
AU - Anahita Mojiri
AU - John P. Cooke
AU - Abhishek Jain
AB - Microphysiological models recapitulating complex vasculature have enabled in vitro evaluation of intricate cellular crosstalk and microenvironmental mechanical cues and stressors. Here, we present a comprehensive review of time and architecture as two under-explored facets required for physiological mimetic vascular models. We conclude with our perspective that incorporating longevity and architecture will improve complex vascular modeling and provide a platform to support chronic disease modeling, personalized medicine, drug testing, and tissue engineering.
BT - npj Biomedical Innovations
DA - 2026-03-25
DO - 10.1038/s44385-026-00077-7
IS - 1
LA - en
N2 - Microphysiological models recapitulating complex vasculature have enabled in vitro evaluation of intricate cellular crosstalk and microenvironmental mechanical cues and stressors. Here, we present a comprehensive review of time and architecture as two under-explored facets required for physiological mimetic vascular models. We conclude with our perspective that incorporating longevity and architecture will improve complex vascular modeling and provide a platform to support chronic disease modeling, personalized medicine, drug testing, and tissue engineering.
PY - 2026
EP - 22
ST - Time and architecture
T2 - npj Biomedical Innovations
TI - Time and architecture: the next two dimensions of microphysiological systems
UR - https://www.nature.com/articles/s44385-026-00077-7
VL - 3
Y2 - 2026-03-25
SN - 3005-1444
ER -