TY - JOUR
KW - 3R principle
KW - animal experimentation
KW - Ethico-epistemic trade-off
KW - Philosophy of science in practice
KW - Replication crisis
KW - Standardisation
AU - Simon Lohse
AB - I discuss reproducibility issues in animal-based research in biomedicine and scrutinise the notion that the causes of non-reproducible results are, by and large, the same as in other disciplines. I argue that there are certain challenges of animal experimentation that are important for a proper analysis of reproducibility problems but have not been sufficiently analysed in this context. I focus on challenges related to standardisation practices and trade-offs between epistemic ideals and moral considerations in animal experimentation. Using an approach that integrates epistemological and ethical perspectives, I explore these challenges and draw out normative consequences of my analysis for the discussion revolving around questionable research practices in animal-based biomedicine and generic reform initiatives.
BT - European Journal for Philosophy of Science
DA - 2026-03-21
DO - 10.1007/s13194-026-00727-y
IS - 2
LA - en
N2 - I discuss reproducibility issues in animal-based research in biomedicine and scrutinise the notion that the causes of non-reproducible results are, by and large, the same as in other disciplines. I argue that there are certain challenges of animal experimentation that are important for a proper analysis of reproducibility problems but have not been sufficiently analysed in this context. I focus on challenges related to standardisation practices and trade-offs between epistemic ideals and moral considerations in animal experimentation. Using an approach that integrates epistemological and ethical perspectives, I explore these challenges and draw out normative consequences of my analysis for the discussion revolving around questionable research practices in animal-based biomedicine and generic reform initiatives.
PY - 2026
EP - 25
T2 - European Journal for Philosophy of Science
TI - Reproducibility, questionable research practices and ethico-epistemic trade-offs in animal-based biomedicine
UR - https://doi.org/10.1007/s13194-026-00727-y
VL - 16
Y2 - 2026-03-24
SN - 1879-4920
ER -