TY - JOUR
AU - Hyesue Jang
AU - Jong Bin Bae
AU - Efthimios Dardiotis
AU - Nikolaos Scarmeas
AU - Perminder S. Sachdev
AU - Darren M. Lipnicki
AU - Ji Won Han
AU - Tae Hui Kim
AU - Kyung Phil Kwak
AU - Bong Jo Kim
AU - Shin Gyeom Kim
AU - Jeong Lan Kim
AU - Seok Woo Moon
AU - Joon Hyuk Park
AU - Seung-Ho Ryu
AU - Jong Chul Youn
AU - Dong Young Lee
AU - Dong Woo Lee
AU - Seok Bum Lee
AU - Jung Jae Lee
AU - Jin Hyeong Jhoo
AU - Mary Yannakoulia
AU - Mary H. Kosmidis
AU - Giorgos M. Hadjigeorgiou
AU - Paraskevi Sakka
AU - Ki Woong Kim
AB - ObjectiveTo investigate the effects of completed pregnancy with childbirth and incomplete pregnancy without childbirth on the late-life cognition and the risk of Alzheimer disease (AD) in women.MethodsUsing the pooled data of 3,549 women provided by 2 population-based cohort studies, we conducted logistic regression analyses to examine retrospectively the associations of completed and incomplete pregnancy with the risks of mild cognitive impairment and AD. For women without dementia, we also conducted analyses of covariance to examine the associations of completed and incomplete pregnancy with Mini-Mental State Examination (MMSE) score.ResultsGrand multiparous women who experienced ≥5 completed pregnancies showed an ≈1.7-fold higher risk of AD than those who experienced 1 to 4 completed pregnancies (odds ratio [OR] 1.68, 95% confidence interval [CI] 1.04–2.72), while those who had incomplete pregnancies showed half the level of AD risk compared with those who never experienced an incomplete pregnancy (OR 0.43, 95% CI 0.24–0.76 for 1 incomplete pregnancy; OR 0.56, 95% CI 0.34–0.92 for ≥2 incomplete pregnancies). In women without dementia, the grand multiparous had worse MMSE scores than those with 1 to 4 completed pregnancies (p < 0.001), while those who experienced ≥1 incomplete pregnancies had better MMSE scores than those who never experienced an incomplete pregnancy (p = 0.008).ConclusionsGrand multiparity was associated with high risk of AD, while incomplete pregnancy was associated with low risk of AD in late life.
BT - Neurology
DA - 2018-08-14
DO - 10.1212/WNL.0000000000006000
IS - 7
N2 - ObjectiveTo investigate the effects of completed pregnancy with childbirth and incomplete pregnancy without childbirth on the late-life cognition and the risk of Alzheimer disease (AD) in women.MethodsUsing the pooled data of 3,549 women provided by 2 population-based cohort studies, we conducted logistic regression analyses to examine retrospectively the associations of completed and incomplete pregnancy with the risks of mild cognitive impairment and AD. For women without dementia, we also conducted analyses of covariance to examine the associations of completed and incomplete pregnancy with Mini-Mental State Examination (MMSE) score.ResultsGrand multiparous women who experienced ≥5 completed pregnancies showed an ≈1.7-fold higher risk of AD than those who experienced 1 to 4 completed pregnancies (odds ratio [OR] 1.68, 95% confidence interval [CI] 1.04–2.72), while those who had incomplete pregnancies showed half the level of AD risk compared with those who never experienced an incomplete pregnancy (OR 0.43, 95% CI 0.24–0.76 for 1 incomplete pregnancy; OR 0.56, 95% CI 0.34–0.92 for ≥2 incomplete pregnancies). In women without dementia, the grand multiparous had worse MMSE scores than those with 1 to 4 completed pregnancies (p < 0.001), while those who experienced ≥1 incomplete pregnancies had better MMSE scores than those who never experienced an incomplete pregnancy (p = 0.008).ConclusionsGrand multiparity was associated with high risk of AD, while incomplete pregnancy was associated with low risk of AD in late life.
PY - 2018
SP - e643
EP - e651
T2 - Neurology
TI - Differential effects of completed and incomplete pregnancies on the risk of Alzheimer disease
UR - https://www.neurology.org/doi/10.1212/WNL.0000000000006000
VL - 91
Y2 - 2026-02-24
ER -