TY - JOUR KW - AI KW - Biomedical Research KW - Funding programme KW - Innovative approaches KW - Methods KW - NAMs KW - Patients KW - prevention KW - Public Health KW - regulatory acceptance KW - translational research KW - Unmet medical needs AU - Francesca Pistollato AU - Fabia Furtmann AU - Sarah Abitbol AU - Marta Agostinho AU - Toni Andreu AU - Bianca Baluta AU - Regina G. H. Beets-Tan AU - Sonja Beken AU - Silvia Ciotti AU - Sandra Coecke AU - Tiago Correia AU - Christian Desaintes AU - Frédéric Destrebecq AU - Philippe Detilleux AU - Sergio Di Virgilio AU - Antigoni Effraimidou AU - Luisa Ferreira Bastos AU - Annalisa Gastaldello AU - Jens K. Habermann AU - Ioan Hanes AU - Mihajlo Jakovljevic AU - Hugh Laverty AU - Benoit Maisonneuve AU - Lindsay J Marshall AU - Dania Movia AU - Giorgia Pallocca AU - Francesco Pappalardo AU - Roberta Pastorino AU - Vilma Radvilaite AU - Kirsty Reid AU - Silke Riegger AU - Giulia Russo AU - Daniela Salvatori AU - Valerie Speirs AU - Marco Straccia AU - Danilo A Tagle AU - Jan Turner AU - Janny van den Eijnden–van Raaij AU - Laura Viviani AU - Helder Constantino AB - The biomedical research landscape is undergoing a transformative shift towards human-centric, interdisciplinary approaches aimed to enhance translational relevance, amplify research impact, and address pressing public health challenges and unmet medical needs (UMNs). Recent European and international ikenitiatives have prioritised the development and implementation of human-centric non-animal methods (NAMs) to increase research translatability, and complement or replace the use of animals in life sciences. Effective cross-sector dialogue among interest-holders is key to align goals, harmonise strategies, and cross-fertilise ideas, ensuring evidence-driven policies that deliver tangible benefits for public health and society. In this spirit, on November 18, 2024, Humane Society International/Europe (since February 14th 2025, Humane World for Animals), on behalf of the Biomedical Research for the 21st Century (BioMed21) Collaboration, hosted a science policy workshop entitled “Leveraging Innovative Research Tools to Meet Public Health Challenges”. This event provided a platform for dialogue among key interest-holders to identify priority areas requiring multidisciplinary interventions. Discussions addressed leveraging innovative technologies to tackle UMNs, reassessing research infrastructure for their future-proof potential, and advancing human-centric tools to drive transformative policy changes. Themes included the societal impact of funded research, standardisation needs, and systems-based solutions to interconnected challenges. This report summarises insights and outputs from the workshop, offering a roadmap to foster impactful, science-driven, and health-focused biomedical research paradigms that meet evolving societal and public health needs. BT - NAM Journal DA - 2025-01-01 DO - 10.1016/j.namjnl.2025.100023 N2 - The biomedical research landscape is undergoing a transformative shift towards human-centric, interdisciplinary approaches aimed to enhance translational relevance, amplify research impact, and address pressing public health challenges and unmet medical needs (UMNs). Recent European and international ikenitiatives have prioritised the development and implementation of human-centric non-animal methods (NAMs) to increase research translatability, and complement or replace the use of animals in life sciences. Effective cross-sector dialogue among interest-holders is key to align goals, harmonise strategies, and cross-fertilise ideas, ensuring evidence-driven policies that deliver tangible benefits for public health and society. In this spirit, on November 18, 2024, Humane Society International/Europe (since February 14th 2025, Humane World for Animals), on behalf of the Biomedical Research for the 21st Century (BioMed21) Collaboration, hosted a science policy workshop entitled “Leveraging Innovative Research Tools to Meet Public Health Challenges”. This event provided a platform for dialogue among key interest-holders to identify priority areas requiring multidisciplinary interventions. Discussions addressed leveraging innovative technologies to tackle UMNs, reassessing research infrastructure for their future-proof potential, and advancing human-centric tools to drive transformative policy changes. Themes included the societal impact of funded research, standardisation needs, and systems-based solutions to interconnected challenges. This report summarises insights and outputs from the workshop, offering a roadmap to foster impactful, science-driven, and health-focused biomedical research paradigms that meet evolving societal and public health needs. PY - 2025 EP - 100023 ST - Leveraging innovative research tools to meet public health challenges T2 - NAM Journal TI - Leveraging innovative research tools to meet public health challenges: a BioMed21 workshop report UR - https://www.sciencedirect.com/science/article/pii/S3050620425000181 VL - 1 Y2 - 2025-11-20 SN - 3050-6204 ER -