TY - JOUR
KW - Analytical biochemistry
KW - Biological models
KW - Biomarkers
KW - Complexity
KW - Stem-cell biotechnology
AU - InWha Park
AU - Hyokyeong Gwon
AU - Yeonjeong Jung
AU - Boyoung Kim
AU - Gaeun Ju
AU - Eugene Sin
AU - Hye In An
AU - Hye Jung Bang
AU - Taegwan Yun
AU - Seung Hwan Lee
AU - Wonsik Lee
AU - Choon-Gon Jang
AU - Hyo-Jong Lee
AU - Chung Sub Kim
AU - Jeongmi Lee
AU - Soah Lee
AB - The study of complex diseases has traditionally relied on reductionist methods, which, although informative, tend to overlook the dynamic interactions and systemic interconnectivity inherent in biological systems. Allostasis, a framework that focuses on physiological adaptations to stress and the maintenance of stability through change, provides a valuable perspective for understanding these diseases. This review summarizes how the allostasis framework defines the cumulative physiological burden—known as allostatic load—imposed by chronic stressors such as persistent psychosocial pressure, drug abuse, and chronic infections. It also explores how adaptive physiological shifts, or changes in allostatic state, contribute to disorders, particularly drug addiction, immune diseases, and cancer. We then review recent studies that uncover stress adaptation mechanisms using cutting-edge technologies, such as multi-omics approaches, induced pluripotent stem cells (iPSCs), and organoid technology. This integrative approach, combining advanced technologies with the allostasis framework, can deepen our understanding of complex disease pathogenesis and inform the development of more effective diagnostic and therapeutic strategies.
BT - Communications Biology
DA - 2025-11-05
DO - 10.1038/s42003-025-08939-3
IS - 1
LA - en
N2 - The study of complex diseases has traditionally relied on reductionist methods, which, although informative, tend to overlook the dynamic interactions and systemic interconnectivity inherent in biological systems. Allostasis, a framework that focuses on physiological adaptations to stress and the maintenance of stability through change, provides a valuable perspective for understanding these diseases. This review summarizes how the allostasis framework defines the cumulative physiological burden—known as allostatic load—imposed by chronic stressors such as persistent psychosocial pressure, drug abuse, and chronic infections. It also explores how adaptive physiological shifts, or changes in allostatic state, contribute to disorders, particularly drug addiction, immune diseases, and cancer. We then review recent studies that uncover stress adaptation mechanisms using cutting-edge technologies, such as multi-omics approaches, induced pluripotent stem cells (iPSCs), and organoid technology. This integrative approach, combining advanced technologies with the allostasis framework, can deepen our understanding of complex disease pathogenesis and inform the development of more effective diagnostic and therapeutic strategies.
PY - 2025
EP - 1526
T2 - Communications Biology
TI - Integrating allostasis and emerging technologies to study complex diseases
UR - https://www.nature.com/articles/s42003-025-08939-3
VL - 8
Y2 - 2025-11-10
SN - 2399-3642
ER -