TY - JOUR
KW - Circadian rhythms
KW - Drug development
KW - Drug regulation
AU - Alastair G. Stewart
AU - Avanka Gunatilaka
AU - Bryan Gao
AB - The incipient use of microphysiological systems (MPSs) in the drug regulatory pathway is based on equivalent or superior predictive value in the evaluation of drug efficacy, safety and toxicology, compared with other novel alternative methods (NAMs) or animal studies. Current MPS practice is not deploying available physiological culture media solutions. Will the clinical translational reliability of MPSs be potentially compromised by the use of hyper-nutritional media?
BT - Nature Reviews Bioengineering
DA - 2025-05
DO - 10.1038/s44222-025-00290-w
IS - 5
LA - en
N2 - The incipient use of microphysiological systems (MPSs) in the drug regulatory pathway is based on equivalent or superior predictive value in the evaluation of drug efficacy, safety and toxicology, compared with other novel alternative methods (NAMs) or animal studies. Current MPS practice is not deploying available physiological culture media solutions. Will the clinical translational reliability of MPSs be potentially compromised by the use of hyper-nutritional media?
PY - 2025
SP - 357
EP - 358
T2 - Nature Reviews Bioengineering
TI - Should culture media for microphysiological systems be nutritionally physiological?
UR - https://www.nature.com/articles/s44222-025-00290-w
VL - 3
Y2 - 2025-10-02
SN - 2731-6092
ER -