TY - JOUR
AU - Shabnam Ghiasvand
AU - Dayananda Siddappa Thimmanahalli
AU - Caroline Morel
AU - Peter Piepenhagen
AU - Dinesh Bangari
AB - Organoids, air-liquid-interface cultures, and microfluidic culture systems are only a few examples of new alternative methods (or new approach methods; NAMs) that have become an increasingly important tool for biopharmaceutical research. Both as a tool for studying disease mechanisms and as a platform for testing novel therapeutics NAMs represent a paradigm shift in translational in-vitro models and offer improved reproducibility and human translatability relative to animal models and simpler cell-based systems. The increasing adoption of NAMs also aligns with FDA Modernization Act 3.0 and increased implementation of the 3Rs principle (Replacement, Reduction, and Refinement) in animal research.
BT - Microscopy and Microanalysis
DA - 2025-07-01
DO - 10.1093/mam/ozaf048.449
IS - Supplement_1
N2 - Organoids, air-liquid-interface cultures, and microfluidic culture systems are only a few examples of new alternative methods (or new approach methods; NAMs) that have become an increasingly important tool for biopharmaceutical research. Both as a tool for studying disease mechanisms and as a platform for testing novel therapeutics NAMs represent a paradigm shift in translational in-vitro models and offer improved reproducibility and human translatability relative to animal models and simpler cell-based systems. The increasing adoption of NAMs also aligns with FDA Modernization Act 3.0 and increased implementation of the 3Rs principle (Replacement, Reduction, and Refinement) in animal research.
PY - 2025
EP - ozaf048.449
T2 - Microscopy and Microanalysis
TI - Advanced Microscopy Techniques for Imaging New Alternative Methods
UR - https://doi.org/10.1093/mam/ozaf048.449
VL - 31
Y2 - 2025-08-27
SN - 1431-9276
ER -