TY - JOUR
KW - Cancer-associated fibroblasts
KW - Esophageal adenocarcinoma
KW - organ-on-a-chip
KW - organoids
AU - Sanjima Pal
AU - Elee Shimshoni
AU - Salvador Flores Torres
AU - Mingyang Kong
AU - Kulsum Tai
AU - Veena Sangwan
AU - Nicholas Bertos
AU - Swneke Donovan Bailey
AU - Julie Bérubé
AU - Donald E. Ingber
AU - Lorenzo Ferri
AB - Esophageal adenocarcinoma (EAC) is the sixth most deadly cancer worldwide, with increasing incidence in North America. As no targeted therapy or immunotherapy has revolutionized the management of EAC, chemotherapy is the only standard of care. Most patients with EAC experience poor outcomes because of the inherent or acquired resistance to chemotherapy.
BT - Journal of Translational Medicine
DA - 2025-05-23
DO - 10.1186/s12967-025-06593-1
IS - 1
N2 - Esophageal adenocarcinoma (EAC) is the sixth most deadly cancer worldwide, with increasing incidence in North America. As no targeted therapy or immunotherapy has revolutionized the management of EAC, chemotherapy is the only standard of care. Most patients with EAC experience poor outcomes because of the inherent or acquired resistance to chemotherapy.
PY - 2025
EP - 577
ST - Patient-derived esophageal adenocarcinoma organ chip
T2 - Journal of Translational Medicine
TI - Patient-derived esophageal adenocarcinoma organ chip: a physiologically relevant platform for functional precision oncology
UR - https://doi.org/10.1186/s12967-025-06593-1
VL - 23
Y2 - 2025-08-04
SN - 1479-5876
ER -