TY - JOUR
KW - Embryonic stem cells
KW - Human disease model
KW - induced pluripotent stem cells
KW - kidney
KW - Kidney disease
KW - microphysiological system
KW - Multipotent Stem Cells
KW - organs-on-chips
KW - Pluripotency
KW - Podocytes
KW - SARS-CoV-2
KW - Stem cell differentiation
KW - Viral infection
AU - Titilola D. Kalejaiye
AU - Rohan Bhattacharya
AU - Samira Musah
AB - Stem cell-derived models offer traceable cell sources for studying tissue development and disease mechanisms. However, many such models have inherently immature or fetal-like phenotypes, limiting their relevance for mechanistic studies of specialized adult tissues. Clinical observations suggest a potential link between epithelial cells and their transit-amplifying progenitors in disease onset and viral tropism, but experimental validation is needed. This study aimed to develop mature visceral epithelial cells (podocytes) from human induced pluripotent stem (iPS) cells using a developmental approach and model severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a vascularized microfluidic kidney-on-a-chip platform exhibiting in vivo-like tissue structure and function.
BT - Cellular and Molecular Bioengineering
DA - 2025-07-22
DO - 10.1007/s12195-025-00851-4
LA - en
N2 - Stem cell-derived models offer traceable cell sources for studying tissue development and disease mechanisms. However, many such models have inherently immature or fetal-like phenotypes, limiting their relevance for mechanistic studies of specialized adult tissues. Clinical observations suggest a potential link between epithelial cells and their transit-amplifying progenitors in disease onset and viral tropism, but experimental validation is needed. This study aimed to develop mature visceral epithelial cells (podocytes) from human induced pluripotent stem (iPS) cells using a developmental approach and model severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a vascularized microfluidic kidney-on-a-chip platform exhibiting in vivo-like tissue structure and function.
PY - 2025
T2 - Cellular and Molecular Bioengineering
TI - A Vascularized Human Organ Chip Reveals SARS-CoV-2 Susceptibility in Developmentally Guided Tissue Maturation
UR - https://doi.org/10.1007/s12195-025-00851-4
Y2 - 2025-08-04
SN - 1865-5033
ER -