TY - JOUR
AU - Fahimeh Shahabipour
AU - Sandro Satta
AU - Mahboobeh Mahmoodi
AU - Argus Sun
AU - Natan Roberto de Barros
AU - Song Li
AU - Tzung Hsiai
AU - Nureddin Ashammakhi
AB - Infectious diseases remain a public healthcare concern worldwide. Amidst the pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 infection, increasing resources have been diverted to investigate therapeutics targeting the COVID-19 spike glycoprotein and to develop various classes of vaccines. Most of the current investigations employ two-dimensional (2D) cell culture and animal models. However, 2D culture negates the multicellular interactions and three-dimensional (3D) microenvironment, and animal models cannot mimic human physiology because of interspecies differences. On the other hand, organ-on-a-chip (OoC) devices introduce a game-changer to model viral infections in human tissues, facilitating high-throughput screening of antiviral therapeutics. In this context, this review provides an overview of the in vitro OoC-based modeling of viral infection, highlighting the strengths and challenges for the future.
BT - Biofabrication
DA - 2023-02
DO - 10.1088/1758-5090/ac6538
IS - 2
LA - en
N2 - Infectious diseases remain a public healthcare concern worldwide. Amidst the pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 infection, increasing resources have been diverted to investigate therapeutics targeting the COVID-19 spike glycoprotein and to develop various classes of vaccines. Most of the current investigations employ two-dimensional (2D) cell culture and animal models. However, 2D culture negates the multicellular interactions and three-dimensional (3D) microenvironment, and animal models cannot mimic human physiology because of interspecies differences. On the other hand, organ-on-a-chip (OoC) devices introduce a game-changer to model viral infections in human tissues, facilitating high-throughput screening of antiviral therapeutics. In this context, this review provides an overview of the in vitro OoC-based modeling of viral infection, highlighting the strengths and challenges for the future.
PY - 2023
EP - 022001
T2 - Biofabrication
TI - Engineering organ-on-a-chip systems to model viral infections
UR - https://dx.doi.org/10.1088/1758-5090/ac6538
VL - 15
Y2 - 2025-05-12
SN - 1758-5090
ER -