TY - JOUR
KW - Antiviral drugs
KW - Gut-on-a-chip
KW - Human organs-on-a-chip
KW - Influenza
KW - Liver-on-a-Chip
KW - lung-on-a-chip
KW - Lymph nodes-on-a-chip
KW - SARS-CoV-2
KW - vaccine
KW - Virology
AU - Jing Li
AU - Haiqing Bai
AU - Zihao Wang
AU - Beibei Xu
AU - Kristen N. Peters Olson
AU - Chengyao Liu
AU - Yinlei Su
AU - Jiawei Hao
AU - Jinying Shen
AU - Xuetong Xi
AU - Jie Zhen
AU - Rong Yu
AU - Yacong Sun
AU - Xin Xie
AU - Wen-xia Tian
AU - Fei Yu
AU - Xiaoheng Liu
AU - Lihe Zhang
AU - Demin Zhou
AU - Longlong Si
AB - Disease models that can accurately recapitulate human pathophysiology during infection and clinical response to antiviral therapeutics are still lacking, which represents a major barrier in drug development. The emergence of human Organs-on-a-Chip that integrated microfluidics with three-dimensional (3D) cell culture, may become the potential solution for this urgent need. Human Organs-on-a-Chip aims to recapitulate human pathophysiology by incorporating tissue-relevant cell types and their microenvironment, such as dynamic fluid flow, mechanical cues, tissue–tissue interfaces, and immune cells to increase the predictive validity of in vitro experimental models. Human Organs-on-a-Chip has a broad range of potential applications in basic biomedical research, preclinical drug development, and personalized medicine. This review focuses on its use in the fields of virology and infectious diseases. We reviewed various types of human Organs-on-a-Chip-based viral infection models and their application in studying viral life cycle, pathogenesis, virus-host interaction, and drug responses to virus- and host-targeted therapies. We conclude by proposing challenges and future research avenues for leveraging this promising technology to prepare for future pandemics.
BT - Organs-on-a-Chip
DA - 2023-12-01
DO - 10.1016/j.ooc.2023.100030
N2 - Disease models that can accurately recapitulate human pathophysiology during infection and clinical response to antiviral therapeutics are still lacking, which represents a major barrier in drug development. The emergence of human Organs-on-a-Chip that integrated microfluidics with three-dimensional (3D) cell culture, may become the potential solution for this urgent need. Human Organs-on-a-Chip aims to recapitulate human pathophysiology by incorporating tissue-relevant cell types and their microenvironment, such as dynamic fluid flow, mechanical cues, tissue–tissue interfaces, and immune cells to increase the predictive validity of in vitro experimental models. Human Organs-on-a-Chip has a broad range of potential applications in basic biomedical research, preclinical drug development, and personalized medicine. This review focuses on its use in the fields of virology and infectious diseases. We reviewed various types of human Organs-on-a-Chip-based viral infection models and their application in studying viral life cycle, pathogenesis, virus-host interaction, and drug responses to virus- and host-targeted therapies. We conclude by proposing challenges and future research avenues for leveraging this promising technology to prepare for future pandemics.
PY - 2023
EP - 100030
T2 - Organs-on-a-Chip
TI - Advancements in organs-on-chips technology for viral disease and anti-viral research
UR - https://www.sciencedirect.com/science/article/pii/S2666102023000058
VL - 5
Y2 - 2025-05-12
SN - 2666-1020
ER -