01850nas a2200253   4500000000100000008004100001260003100042653001200073653002300085653005100108653001700159653002100176100002000197700001500217700001900232700002300251700002300274700002300297245008700320856007500407300001200482520108000494020002201574       2027                            d  c2027-01-01bAcademic Press10abiobank10aBiobank governance10aEthical, Legal, and Social Implications (ELSI)10aHuman tissue10ainformed consent1 aVictoria Corbit1 aAzra Hasan1 aThomas J. Bell1 aMelissa W. VonDran1 aCatharine E. Krebs1 aGail A. Van Norman00aChapter 10 - Biobanks: Yielding extraordinary returns for human health and disease  uhttps://www.sciencedirect.com/science/article/pii/B9780443265143000035  a159-1753 aHuman tissues serve as an ideal model system for expanding our understanding of human health and disease because they allow researchers to connect mechanistic findings from cell models with relevant applications in humans. Access to human biospecimens is made possible by biobanks that procure, store, and distribute samples for research. The types of samples available in biorepositories around the world vary widely in sample type, donor demographics, and preservation methods, enabling research across a range of areas. This chapter describes key information for researchers interested in conducting research with human biospecimens. We describe the following: (1) the options for obtaining human tissue for research and the different types of bioresources that exist; (2) ethical and legal requirements for human biospecimen collections and implications for biobank governance, including informed consent, and (3) innovations within biospecimen and biorepository science that are enhancing rigor, reproducibility, and the increased use of human biospecimens for research.  a978-0-443-26514-3