01241nas a2200181   4500000000100000000000100001008004100002260001500043653003500058653001200093653002200105245008900127856005500216300000900271490000700280520075800287022001401045       2026                            d  c2026-08-2710aHumanities and Social Sciences10aScience10amultidisciplinary00a5 perspectives on translating microphysiological systems from concept to application  uhttps://www.nature.com/articles/s41467-026-77111-0  a91480 v173 aMicrophysiological Systems (MPS) feature cells, often cultured in 3D, within a microfluidic circuit aiming to mimic the circulation and cross-talk between organs found in the human body. These platforms have proven useful in different contexts, ranging from basic biology research to disease modelling and drug development - all with the underlying aim of reducing our reliance on animal experiments. In addition to dedicating a “cross-journal collection [https://www.nature.com/collections/fgjeddegjc]” to this topic, we wanted to delve deeper into the key steps to translating MPS from concept to application, identifying the role of different players, showcasing the associated challenges and learning about the future outlook of this technology.  a2041-1723