01646nas a2200313   4500000000100000000000100001008004100002260001500043653002400058653003400082653002500116653002200141653002400163100002100187700001700208700001500225700002200240700001700262700001600279700001900295700001600314700001800330245006200348856005500410300000900465490000700474520083700481022001401318       2024                            d  c2024-03-1210aAlzheimer's disease10aamyotrophic lateral sclerosis10aHuntington's disease10aNeurodegeneration10aParkinson's disease1 aSarnai Amartumur1 aHuong Nguyen1 aThuy Huynh1 aTestaverde S. Kim1 aRan-Sook Woo1 aEungseok Oh1 aKyeong Kyu Kim1 aLuke P. Lee1 aChaejeong Heo00aNeuropathogenesis-on-chips for neurodegenerative diseases  uhttps://www.nature.com/articles/s41467-024-46554-8  a22190 v153 aDeveloping diagnostics and treatments for neurodegenerative diseases (NDs) is challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro systems that recapitulate patient-like pathophysiology are emerging as alternatives to conventional animal-based models. In this review, we explore the interconnected pathogenic features of different types of ND, discuss the general strategy to modelling NDs using a microfluidic chip, and introduce the organoid-on-a-chip as the next advanced relevant model. Lastly, we overview how these models are being applied in academic and industrial drug development. The integration of microfluidic chips, stem cells, and biotechnological devices promises to provide valuable insights for biomedical research and developing diagnostic and therapeutic solutions for NDs.  a2041-1723