00711nas a2200169   4500000000100000000000100001008004100002260001500043653002100058653001100079100001900090245007700109856005500186300000800241520027800249022001400527       2026                            d  c2026-07-2210aDrug development10apolicy1 aNatalie Burden00aNew approach methodologies to reduce reliance on animal toxicity testing  uhttps://www.nature.com/articles/s44222-026-00480-0  a1-23 aNew approach methodologies are transforming safety science towards more human-relevant, mechanistic models. Bioengineers are central to this shift, but their impact depends on delivering systems that are relevant, robust, scalable and bridge the research-to-regulation gap.  a2731-6092