01006nas a2200241   4500000000100000000000100001008004100002260001200043653003000055653002100085653001900106653002300125653002700148100001700175700002600192700001800218245006200236856005500298300001200353490000600365520037900371022001400750       2026                            d  c2026-0510aBiomaterials – proteins10aDrug development10aDrug screening10aTissue engineering10atranslational research1 aMariana Dias1 aCatarina A. Custódio1 aJoão F. Mano00aHuman protein-based biomaterials in preclinical modelling  uhttps://www.nature.com/articles/s44222-026-00425-7  a399-4000 v43 aHuman protein-based biomaterials facilitate the development of preclinical models that integrate predictive value and ethical responsibility. Metatissue uses decellularized extracellular matrix from placenta samples and human blood to create tunable, xeno-free substrates for 3D cell culture, minimizing the reliance on animal models and accelerating translational research.  a2731-6092