01096nas a2200157   4500000000100000008004100001260001500042100001600057700001800073245004800091856004300139300001200182490000700194520072300201022001400924       2026                            d  c2026-01-011 aImaan Ahmed1 aAbbas Shafiee00aSkin organoids as a new biological standard  uhttps://doi.org/10.1093/burnst/tkag033  atkag0330 v143 aEarly in vitro models of human skin included two-dimensional cell cultures using keratinocytes and fibroblasts. Though cost-effective and simple to produce, these monolayers fail to recapitulate the skin’s three-dimensional structure. Further progress saw the layering of keratinocytes on top of fibroblasts, to create a three-dimensional ‘skin equivalent’. These could be increased in anatomical and functional relevance with the addition of other populations, such as dermal papilla cells to induce hair growth. However, hair growth in these in vitro constructs was often incomplete. Furthermore, these constructs lacked the diverse cell populations present within the human skin organ (Supplementary Table 1).  a2321-3876