00569nas a2200121   4500000000100000000000100001008003900002260002000041100001900061245008800080856013300168520014600301       0                             d  cAugust 26, 20261 aMichael Phelan00aIt Is Time To Require Human-Relevant Efficacy Evidence Before First-In-Human Trials  uhttps://www.drugdiscoveryonline.com/doc/it-is-time-to-require-human-relevant-efficacy-evidence-before-first-in-human-trials-00013 aWhy, when human-relevant evidence of likely efficacy can be generated before a trial begins, is it not evaluated before patients are exposed?