02088nas a2200337   4500000000100000000000100001008004100002260001500043653002600058653001700084653002600101653002100127653001500148100002000163700001600183700001700199700001400216700001600230700001900246700001600265700002500281700001900306700001700325700001600342245018800358856005500546300001000601490000700611520111800618022001401736       2026                            d  c2026-07-2810aBiological techniques10aCell biology10aDevelopmental biology10amedical research10aPhysiology1 aCristina Antich1 aYu-Chi Chen1 aJustine Noel1 aYanyan Qu1 aYuhong Fang1 aShayne Frebert1 aDingyin Tao1 aLauren S. Richardson1 aRamkumar Menon1 aMin Jae Song1 aMarc Ferrer00aRecapitulating gestational progression: a high-throughput 3D bioprinted vascularized human placenta demonstrating stage-specific molecular and functional signatures of human pregnancy  uhttps://www.nature.com/articles/s41598-026-61708-y  a241400 v163 aThe placenta is a highly dynamic organ that supports the growth and development of the fetus during gestation. Malfunction of the placenta causes disorders of the pregnancy, including preeclampsia and pre-term birth. The study of the pathophysiology of the placenta throughout pregnancy has been hindered by limited access to the human placenta and lack of predictive cellular and animal models. Here, we describe 3D bioprinted human placenta barrier (hPB) tissue models using primary human trophoblasts and stroma cells that recapitulate the physiology of the human placenta at early and late stages of gestation. These bioprinted vascularized hPB tissue models mimic the architecture and function early and late-stages human placenta, including barrier function, nutrient uptake, transporters activity and hormones secretion. Assembled in a 96-well transwell plate format, this deeply characterized platform provides a robust high-fidelity system for predictive screening of therapeutics and potentially hazardous agents for placenta diseases and safety, and a better understanding of placental pathophysiology.  a2045-2322