02552nas a2200241   4500000000100000000000100001008004100002260001500043653002000058653001700078653002600095653002300121653001800144100003000162700001900192700002200211700001400233700002000247700002400267245011700291856007800408520182400486       2026                            d  c2026-01-0110aanimal research10apublic trust10ascience communication10atrusted messengers10aVeterinarians1 aSally A. Thompson-Iritani1 aNeera V. Gopee1 aJoseph T. Newsome1 aTodd Bear1 aBrianna Skinner1 aPatricia A. Preisig00aA national survey on public opinions about research involving animals: veterinarians are the most trusted source  uhttps://avmajournals.avma.org/view/journals/ajvr/87/1/ajvr.25.06.0190.xml3 aObjective To identify ways that trusted sources, such as veterinarians, scientists, and other professionals, can promote open and ethical communication about animal research while also assessing public attitudes and preferences. Methods An observational study analyzed responses from a national sample of 2,028 US adults (N = 2,860) recruited using nonprobability quota sampling through the Lucid platform. Participants (≥ 18 years; 50 states and the District of Columbia) completed an online survey from February 7 through 9, 2023. Exclusions applied for ineligibility, failed attentiveness checks, incomplete responses, or unusually short completion times. The 37-item survey measured knowledge, attitudes, trust in sources, and reactions to messages supporting and opposing animal research. Data were weighted to 2021 US Census benchmarks. Analyses included subgroup comparisons by gender, education, and political ideology. Results A total of 2,028 valid responses were included in the analysis. Attitudes varied across demographics and were shaped by perceptions of humane care and credibility of information. Veterinarians were the most trusted source (81%), followed by scientists, medical doctors, and professors. Messages highlighting ethical oversight and mutual benefits for humans and animals increased acceptance (from 44% to 55%) and reduced strong opposition (from 50% to 35%). Conclusions Veterinarians and other trusted professionals play an essential role in supporting accurate public understanding of research involving animals. Clear, fact-based communication encourages informed engagement with complex scientific and ethical issues. Clinical Relevance Veterinarians are well positioned to lead public dialogue about animal research through informed, balanced, and welfare-focused communication.