01487nas a2200337   4500000000100000000000100001008004100002260001500043653002500058653002100083653002600104653002800130653002100158100002000179700001800199700001700217700001700234700002300251700002000274700002500294700002900319700003100348700002300379700001800402245009700420856004700517300000800564490000700572520055600579022001401135       2026                            d  c2026-05-0610acardiac microtissues10aCardiorenal axis10aDrug-induced toxicity10aInter-organ interaction10aKidney organoids1 aBeatrice Gabbin1 aJames Gallant1 aFangchen Liu1 aHailiang Mei1 aBerend J. van Meer1 aTon J. Rabelink1 aChristine L. Mummery1 aJessica M. Vanslambrouck1 aCathelijne W. van den Berg1 aViviana Meraviglia1 aMilena Bellin00aIn vitro modeling of renal injury-induced cardiac effects using human iPSC-derived organoids  uhttps://doi.org/10.1186/s12964-026-02902-3  a3800 v243 aThe bidirectional communication between the heart and kidney is essential for physiological homeostasis, with injury in one organ often impairing the other. Although cardiorenal crosstalk is clinically relevant in conditions such as cardiorenal syndrome (CRS), the underlying molecular and cellular mechanisms remain poorly understood, and in vitro models are lacking. Here, we developed a co-culture system using human induced pluripotent stem cell (hiPSC)-derived kidney organoids (kOs) and cardiac microtissues (cMTs) to model the cardiorenal axis.  a1478-811X