01722nas a2200613 4500000000100000000000100001008004100002260001500043653001800058653001700076653001700093653003100110653002300141653000900164653001200173653003100185653001200216653002700228653002000255100002500275700001800300700002400318700002100342700001600363700001800379700002100397700001500418700003400433700002100467700001600488700001700504700001700521700001300538700001600551700002200567700002600589700001600615700002000631700002700651700002000678700001700698700002100715700002900736700002100765700001900786700001800805700002300823700002100846700002200867245012500889856007401014490000601088022001401094 2026 d c2026-06-1110aGLP1R agonist10aGnRH neurons10aPOMC neurons10aautomated biomanufacturing10ahuman hypothalamus10aiPSC10aInsulin10ametabolic disease modeling10aObesity10aPluripotent Stem Cells10atype 2 diabetes1 aVukasin M. Jovanovic1 aNarisu Narisu1 aLori L. Bonnycastle1 aDavid Castellano1 aSeungmi Ryu1 aRavi Tharakan1 aKendall T. Mesch1 aQiang Chen1 aFahrünisa Meryem Betül Erol1 aHannah J. Glover1 aTingfen Yan1 aNeelam Sinha1 aChaitali Sen1 aShu Yang1 aDvir Blivis1 aDaniel F. Bennett1 aGiovanni Rosales-Soto1 aJason Inman1 aPinar Ormanoglu1 aChristopher A. LeClair1 aNatalie D. Shaw1 aMenghang Xia1 aMartin Schneider1 aErick O. Hernandez-Ochoa1 aMichael R. Erdos1 aAnton Simeonov1 aShuibing Chen1 aFrancis S. Collins1 aClaudia A. Doege1 aCarlos A. Tristan00aScalable hypothalamic neuron differentiation from human pluripotent stem cells suitable for modeling metabolic disorders uhttps://www.cell.com/stem-cell-reports/abstract/S2213-6711(26)00169-40 v0 a2213-6711