01114nas a2200157   4500000000100000008004100001260001500042100002200057700002000079700002000099245008900119856005900208300001400267490000700281520066800288       2013                            d  c2013-08-131 aEvelien De Clercq1 aIsabelle Kalmar1 aDaisy Vanrompay00aAnimal Models for Studying Female Genital Tract Infection with Chlamydia trachomatis  uhttps://journals.asm.org/doi/full/10.1128/iai.00357-13  a3060-30670 v813 aChlamydia trachomatis is a Gram-negative obligate intracellular bacterial pathogen. It is the leading cause of bacterial sexually transmitted disease in the world, with more than 100 million new cases of genital tract infections with C. trachomatis occurring each year. Animal models are indispensable for the study of C. trachomatis infections and the development and evaluation of candidate vaccines. In this paper, the most commonly used animal models to study female genital tract infections with C. trachomatis will be reviewed, namely, the mouse, guinea pig, and nonhuman primate models. Additionally, we will focus on the more recently developed pig model.