02350nas a2200469   4500000000100000008004100001260001500042653001700057653003000074653001700104653001700121100002000138700001700158700001600175700002100191700001700212700002000229700001800249700002200267700001700289700001900306700002300325700002500348700002000373700001700393700002300410700001700433700002100450700001700471700002000488700002600508700002400534700002000558700001900578700002100597245011600618856005000734300001200784490000600796520106900802022000901871       2023                            d  c2023-12-3110acell culture10aevidence-based toxicology10arisk of bias10auser testing1 aGro H. Mathisen1 aGunn E. Vist1 aPaul Whaley1 aRichard A. White1 aTrine Husøy1 aHeather M. Ames1 aAnna Beronius1 aEmma Di Consiglio1 aIngrid Druwe1 aThomas Hartung1 aSebastian Hoffmann1 aCarlijn R. Hooijmans1 aKyriaki Machera1 aPilar Prieto1 aJoshua F. Robinson1 aErwin Roggen1 aAndrew A. Rooney1 aNicolas Roth1 aEliana Spilioti1 aAnastasia Spyropoulou1 aOlga Tcheremenskaia1 aEmanuela Testai1 aMathieu Vinken1 aCamilla Svendsen00aProtocol: Testing the Performance of INVITES-IN, A Tool for Assessing the Internal Validity of In Vitro Studies  uhttps://doi.org/10.1080/2833373X.2023.2293289  a22932890 v13 aA tool for evaluation of internal validity of in vitro studies called INVITES-IN is currently under development. The tool is designed specifically for cell culture studies. This protocol describes the testing of the performance of INVITES-IN. By performance, we mean the extent to which results of using INVITES-IN are the same for different users (consistency), the amount of time and cognitive effort it takes to apply INVITES-IN (assessor workload), the precision and potential for systematic error in results of applying INVITES-IN (accuracy), and how easy it is to use INVITES-IN (user experience). The participants in the user testing will be representative for the expected end-users of INVITES-IN which are persons preparing literature reviews including in vitro studies (e.g. in the context of chemical hazard and risk assessments or drug development). All end-users are expected to have experience with in vitro methods. Data collected from the performance testing will be used for further refinement and development of the release version of INVITES-IN.  anull