01011nas a2200277   4500000000100000000000100001008004100002260001500043100001800058700001900076700001700095700002200112700001600134700001800150700001900168700001900187700002100206700001900227700001800246700002000264700002800284245005200312856004700364520030800411022001400719       2026                            d  c2026-04-171 aCéline Heinl1 aNuno H. Franco1 aBettina Bert1 aKatherina Siewert1 aDania Movia1 aEdlira Aruçi1 aCarina Ladeira1 aAhmed Y. Sanin1 aWinfried Neuhaus1 aUlf D. Kahlert1 aManosij Ghosh1 aAurélie Thomas1 aAthanassia Sotiropoulos00aA call for preregistration of in vitro research  uhttps://doi.org/10.1038/s44319-026-00764-x3 aThis article highlights the benefits of preregistration in improving the reliability and transparency of in vitro studies. By preregistering their studies, researchers can make their findings more reproducible, paving the way for medical progress, and accelerating the replacement of animal experiments.  a1469-3178