02824nas a2200433   4500000000100000000000100001008004100002260001500043653002600058653001800084653001600102653001700118100001700135700001900152700001200171700002300183700002000206700001400226700001900240700001800259700001800277700001500295700001900310700001600329700001900345700001900364700002200383700001300405700001800418700001700436700002000453700002200473245012700495856005500622300000700677490000600684520168600690022001402376       2026                            d  c2026-04-0110aBiological techniques10aBiotechnology10aEngineering10aNeuroscience1 aNavya Mishra1 aRajaram Kaveti1 aPei Liu1 aBaha Erim Uzunoglu1 aAram Mirabedini1 aAnna Tran1 aZ. Begum Yagci1 aTyler Johnson1 aParvez Ahmmed1 aQiuli Wang1 aJeong Yong Kim1 aParis Brown1 aSurjendu Maity1 aShyni Varghese1 aMichael D. Dickey1 aYong Zhu1 aAlper Bozkurt1 aRaudel Avila1 aAlbert J. Keung1 aAmay J. Bandodkar00aCarbon nanotube microelectrode arrays enable scalable and accessible electrophysiological recordings of cerebral organoids  uhttps://www.nature.com/articles/s44328-026-00088-9  a200 v33 aHuman cerebral organoids hold promise for studying neurodevelopment, modelling disease, and drug screening. Electrophysiology is a key functional property for these studies; yet, performing high-throughput electrophysiological studies with organoids remains a critical bottleneck. Current state-of-the-art recording technologies, including 2D and 3D microelectrode arrays (MEAs), are low-throughput, expensive to fabricate and purchase, and often incompatible with routine organoid culture. These limitations restrict their adoption, and many studies report electrophysiological activity from insufficient sample sizes to accurately capture the widely accepted biological variability inherent to organoid models. Here, we present a scalable, low-cost, plug-and-play platform that integrates a new class of carbon nanotube-based 3D microelectrode arrays into standard cell culture plates. This system enables high-throughput extracellular recordings from many organoids without specialised workflows. Using this system, we record electrophysiological signals from 74 human cortical organoids, the largest scale reported in organoid electrophysiology studies to the best of our knowledge. The measurements involve capturing electrophysiological phenotypes across neurotypical and Angelman Syndrome organoids. We also show that the use of carbon nanotubes in place of conventional gold electrodes achieves superior electrical, electrochemical, and electromechanical properties at a fraction of the cost while enabling a new scalable manufacturing technique. This technology establishes a standardised and accessible route to large-scale electrophysiological measurements in organoids.  a3004-8656