01036nas a2200145 4500000000100000008004100001260001200042100001900054245013500073856007000208300001200278490000700290520057900297022001400876 2026 d c2026-061 aDavid I. Lewis00aReducing, and ultimately replacing, the involvement of animals in education: legislative, ethical, and societal drivers for change uhttps://journals.physiology.org/doi/full/10.1152/advan.00220.2025 a374-3780 v503 aNEW & NOTEWORTHY Learners are increasingly objecting to participating in educational activities that involve animals. There is a substantial drive from regulators and funders globally to replace the involvement of animals in research. There is no going back. Educators, educational leaderships, physiological societies, and others need to embrace change, working collaboratively to reimagine nonanimal technologies and new approach methodologies used in research to create educationally robust, humane alternatives to the current educational activities that involve animals. a1043-4046