01475nas a2200229   4500000000100000000000100001008004100002260001500043653001700058653002700075653003100102653003800133653002300171653002000194100001600214245011300230856004700343300000700390490000700397520082700404022001401231       2026                            d  c2026-03-2110a3R principle10aanimal experimentation10aEthico-epistemic trade-off10aPhilosophy of science in practice10aReplication crisis10aStandardisation1 aSimon Lohse00aReproducibility, questionable research practices and ethico-epistemic trade-offs in animal-based biomedicine  uhttps://doi.org/10.1007/s13194-026-00727-y  a250 v163 aI discuss reproducibility issues in animal-based research in biomedicine and scrutinise the notion that the causes of non-reproducible results are, by and large, the same as in other disciplines. I argue that there are certain challenges of animal experimentation that are important for a proper analysis of reproducibility problems but have not been sufficiently analysed in this context. I focus on challenges related to standardisation practices and trade-offs between epistemic ideals and moral considerations in animal experimentation. Using an approach that integrates epistemological and ethical perspectives, I explore these challenges and draw out normative consequences of my analysis for the discussion revolving around questionable research practices in animal-based biomedicine and generic reform initiatives.  a1879-4920