01809nas a2200229   4500000000100000000000100001008004100002260001500043653002000058653001500078653002000093653001100113653001600124653001300140100002300153245009900176856004700275300000700322490000700329520122900336022001401565       2026                            d  c2026-01-2910aanimal research10aInnovation10aMaterial models10apolicy10areplacement10aThree Rs1 aNico Dario Müller00aLane-Petter’s Pipeline: Why reliably decreasing animal research takes more than replacements  uhttps://doi.org/10.1007/s13194-025-00715-8  a100 v163 aPrograms for the “three Rs” of “replace, reduce, refine” (Russell & Burch 1959) aim to make science more compatible with animal protection. This article draws attention to a major obstacle to that endeavor: While some animal models are being replaced by alternatives, new animal models are also being developed. Animal research thus resembles a moving pipeline, not a fixed set of models, as British scientist and regulator William Lane-Petter noted over half a century ago (Lane-Petter 1961). This article provides an account of “Lane-Petter’s Pipeline” (LPP) by drawing on philosophical literature on animal models and advances two claims: First, there is practically infinite room for the innovation of new animal models, so LPP can continue to move indefinitely unless policy intervenes; Second, the extent to which innovation focuses on new animal models rather than new non-animal-models plausibly depends on scientific repertoires (Ankeny & Leonelli, 2016) and the built environment of scientific work, which policy can help to shape. This highlights the potential, and the need, for strategic policies that tilt the environment of innovation towards new non-animal-models rather than new animal models.  a1879-4920