02739nas a2200433   4500000000100000008004100001260001500042100001600057700001700073700002400090700002200114700002500136700002300161700001500184700001600199700002000215700001600235700001900251700001800270700001800288700001900306700001700325700001900342700001900361700001700380700001700397700001700414700002000431700002100451700002100472700002900493700002000522700001700542245009800559856006300657300001400720490000700734520156400741       2018                            d  c2018-08-141 aHyesue Jang1 aJong Bin Bae1 aEfthimios Dardiotis1 aNikolaos Scarmeas1 aPerminder S. Sachdev1 aDarren M. Lipnicki1 aJi Won Han1 aTae Hui Kim1 aKyung Phil Kwak1 aBong Jo Kim1 aShin Gyeom Kim1 aJeong Lan Kim1 aSeok Woo Moon1 aJoon Hyuk Park1 aSeung-Ho Ryu1 aJong Chul Youn1 aDong Young Lee1 aDong Woo Lee1 aSeok Bum Lee1 aJung Jae Lee1 aJin Hyeong Jhoo1 aMary Yannakoulia1 aMary H. Kosmidis1 aGiorgos M. Hadjigeorgiou1 aParaskevi Sakka1 aKi Woong Kim00aDifferential effects of completed and incomplete pregnancies on the risk of Alzheimer disease  uhttps://www.neurology.org/doi/10.1212/WNL.0000000000006000  ae643-e6510 v913 aObjectiveTo investigate the effects of completed pregnancy with childbirth and incomplete pregnancy without childbirth on the late-life cognition and the risk of Alzheimer disease (AD) in women.MethodsUsing the pooled data of 3,549 women provided by 2 population-based cohort studies, we conducted logistic regression analyses to examine retrospectively the associations of completed and incomplete pregnancy with the risks of mild cognitive impairment and AD. For women without dementia, we also conducted analyses of covariance to examine the associations of completed and incomplete pregnancy with Mini-Mental State Examination (MMSE) score.ResultsGrand multiparous women who experienced ≥5 completed pregnancies showed an ≈1.7-fold higher risk of AD than those who experienced 1 to 4 completed pregnancies (odds ratio [OR] 1.68, 95% confidence interval [CI] 1.04–2.72), while those who had incomplete pregnancies showed half the level of AD risk compared with those who never experienced an incomplete pregnancy (OR 0.43, 95% CI 0.24–0.76 for 1 incomplete pregnancy; OR 0.56, 95% CI 0.34–0.92 for ≥2 incomplete pregnancies). In women without dementia, the grand multiparous had worse MMSE scores than those with 1 to 4 completed pregnancies (p < 0.001), while those who experienced ≥1 incomplete pregnancies had better MMSE scores than those who never experienced an incomplete pregnancy (p = 0.008).ConclusionsGrand multiparity was associated with high risk of AD, while incomplete pregnancy was associated with low risk of AD in late life.