01262nas a2200277   4500000000100000000000100001008004100002260001500043653002600058653001800084653001600102653002100118653001500139100001400154700001800168700001600186700001700202700001700219700001800236245010700254856005500361300000700416490000600423520054100429022001400970       2026                            d  c2026-02-0210aBiological techniques10aBiotechnology10aEngineering10amedical research10aStem cells1 aDohui Kim1 aJaeseung Youn1 aJuhyeok Kim1 aJeongmin Lee1 aJangwon Yoon1 aDong Sung Kim00aFrom organoid culture to manufacturing: technologies for reproducible and scalable organoid production  uhttps://www.nature.com/articles/s44385-025-00054-6  a120 v33 aIn this review, we systematically categorize diverse organoid engineering strategies—including cellular programming, material engineering, and platform- or system-level innovations—according to their impact on reproducibility and scalability, and highlight representative applications and emerging directions. By reframing organoid generation as a manufacturing process, these technological advances pave the way toward standardized and high-fidelity organoid production for both fundamental research and translational applications.  a3005-1444