03867nas a2200757   4500000000100000008004100001260001500042653000700057653002400064653002200088653002600110653001200136653000900148653001300157653001500170653001800185653002600203653002700229653002400256100002500280700001900305700001800324700002000342700001600362700001800378700002700396700001600423700001800439700001800457700001800475700002400493700002600517700002300543700002300566700002500589700002600614700002500640700002200665700001500687700002400702700001700726700002300743700002300766700001600789700002100805700002500826700002200851700002100873700001600894700001800910700001700928700002200945700001900967700001900986700001901005700001501024700003801039700001801077700002301095245010201118856007201220300001101292490000601303520178601309022001403095       2025                            d  c2025-01-0110aAI10aBiomedical Research10aFunding programme10aInnovative approaches10aMethods10aNAMs10aPatients10aprevention10aPublic Health10aregulatory acceptance10atranslational research10aUnmet medical needs1 aFrancesca Pistollato1 aFabia Furtmann1 aSarah Abitbol1 aMarta Agostinho1 aToni Andreu1 aBianca Baluta1 aRegina G. H. Beets-Tan1 aSonja Beken1 aSilvia Ciotti1 aSandra Coecke1 aTiago Correia1 aChristian Desaintes1 aFrédéric Destrebecq1 aPhilippe Detilleux1 aSergio Di Virgilio1 aAntigoni Effraimidou1 aLuisa Ferreira Bastos1 aAnnalisa Gastaldello1 aJens K. Habermann1 aIoan Hanes1 aMihajlo Jakovljevic1 aHugh Laverty1 aBenoit Maisonneuve1 aLindsay J Marshall1 aDania Movia1 aGiorgia Pallocca1 aFrancesco Pappalardo1 aRoberta Pastorino1 aVilma Radvilaite1 aKirsty Reid1 aSilke Riegger1 aGiulia Russo1 aDaniela Salvatori1 aValerie Speirs1 aMarco Straccia1 aDanilo A Tagle1 aJan Turner1 aJanny van den Eijnden–van Raaij1 aLaura Viviani1 aHelder Constantino00aLeveraging innovative research tools to meet public health challenges: a BioMed21 workshop report  uhttps://www.sciencedirect.com/science/article/pii/S3050620425000181  a1000230 v13 aThe biomedical research landscape is undergoing a transformative shift towards human-centric, interdisciplinary approaches aimed to enhance translational relevance, amplify research impact, and address pressing public health challenges and unmet medical needs (UMNs). Recent European and international ikenitiatives have prioritised the development and implementation of human-centric non-animal methods (NAMs) to increase research translatability, and complement or replace the use of animals in life sciences. Effective cross-sector dialogue among interest-holders is key to align goals, harmonise strategies, and cross-fertilise ideas, ensuring evidence-driven policies that deliver tangible benefits for public health and society. In this spirit, on November 18, 2024, Humane Society International/Europe (since February 14th 2025, Humane World for Animals), on behalf of the Biomedical Research for the 21st Century (BioMed21) Collaboration, hosted a science policy workshop entitled “Leveraging Innovative Research Tools to Meet Public Health Challenges”. This event provided a platform for dialogue among key interest-holders to identify priority areas requiring multidisciplinary interventions. Discussions addressed leveraging innovative technologies to tackle UMNs, reassessing research infrastructure for their future-proof potential, and advancing human-centric tools to drive transformative policy changes. Themes included the societal impact of funded research, standardisation needs, and systems-based solutions to interconnected challenges. This report summarises insights and outputs from the workshop, offering a roadmap to foster impactful, science-driven, and health-focused biomedical research paradigms that meet evolving societal and public health needs.  a3050-6204