01835nas a2200325   4500000000100000008004100001260001500042653001200057653002400069653002400093653001200117653002900129653002400158653002900182653001500211653001300226100002500239700001900264700002500283700002200308700001600330700002300346700002300369245015200392856004700544300000900591490000700600520088800607022001401495       2025                            d  c2025-09-2410aAnimals10aBiomedical Research10aFramework programme10aFunding10aHuman-centric approaches10aInfectious diseases10aNoncommunicable diseases10aprevention10aProjects1 aFrancesca Pistollato1 aFabia Furtmann1 aAnnalisa Gastaldello1 aRoberta Pastorino1 aEleni Petra1 aIgnacio J. Tripodi1 aHelder Constantino00aBridging the prevention gap: funding distribution and methodological shifts in prevention-focused biomedical research under EU framework programmes  uhttps://doi.org/10.1186/s12967-025-07019-8  a10060 v233 aNoncommunicable diseases (NCDs) contribute significantly to global morbidity and mortality, accounting for 74% of all deaths worldwide. Many of these chronic diseases can be prevented or their onset mitigated through lifestyle interventions. Complementing these efforts, robust biomarkers enable early diagnosis (secondary prevention), while tertiary prevention can reduce long-term complications and improve disease management. Moreover, the importance of prevention extends beyond NCDs to infectious diseases, where lifestyle-related factors can also play a pivotal role. Innovative human-based research methods have shown suitable for modeling several diseases and advancing drug discovery. These approaches are particularly relevant in prevention research, given the inherently human nature of the lifestyle and environmental factors associated with disease risk and progression.  a1479-5876