01703nas a2200313   4500000000100000000000100001008004100002260001500043653002500058653002400083653003500107653001100142653001900153653003000172653002700202653002000229653001700249653001400266653001500280653003000295653002000325100002600345700002300371700001700394245011400411856004700525520080300572022001401375       2025                            d  c2025-07-2210aEmbryonic stem cells10aHuman disease model10ainduced pluripotent stem cells10akidney10aKidney disease10amicrophysiological system10aMultipotent Stem Cells10aorgans-on-chips10aPluripotency10aPodocytes10aSARS-CoV-210aStem cell differentiation10aViral infection1 aTitilola D. Kalejaiye1 aRohan Bhattacharya1 aSamira Musah00aA Vascularized Human Organ Chip Reveals SARS-CoV-2 Susceptibility in Developmentally Guided Tissue Maturation  uhttps://doi.org/10.1007/s12195-025-00851-43 aStem cell-derived models offer traceable cell sources for studying tissue development and disease mechanisms. However, many such models have inherently immature or fetal-like phenotypes, limiting their relevance for mechanistic studies of specialized adult tissues. Clinical observations suggest a potential link between epithelial cells and their transit-amplifying progenitors in disease onset and viral tropism, but experimental validation is needed. This study aimed to develop mature visceral epithelial cells (podocytes) from human induced pluripotent stem (iPS) cells using a developmental approach and model severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a vascularized microfluidic kidney-on-a-chip platform exhibiting in vivo-like tissue structure and function.  a1865-5033