@article{bibcite_9241,
  keywords = {Alzheimer{\textquoteright}s disease, Diagnostic markers},
  author = {Aram Aslanyan and Soumya Mukherjee and Eleanor M. Moncur and Alicja Szadziewska and Yingxin He and Przemys{\l}aw R. Kac and Reid Coyle and Elena Camporesi and Chihiro Sato and Nupur Ghoshal and Nicolas R. Barth{\'e}lemy and Jack Wood and Junyue Ge and Maciej Dulewicz and Srinivas Koutarapu and Katherine Schwetye and Kaleigh F. Roberts and Eimear C. Murphy and Francesco Carletti and Kaj Blennow and Fernando Gonzalez Ortiz and Claire A. Leckey and Tatiana A. Giovannucci and Kanza Tariq and Henrik Zetterberg and Donald L. Elbert and Lewis Thorne and Ahmed K. Toma and Laurence Watkins and Nick C. Fox and Randall J. Bateman and J{\"o}rg Hanrieder and Ross W. Paterson},
  title = {Spatiotemporal characterization of Alzheimer disease pathology in living human brain tissue},
  abstract = {Alzheimer disease begins in the brain many years before symptoms, but early changes are usually studied after death or indirectly through fluid and imaging biomarkers. Here we show that small brain biopsies collected during ventriculoperitoneal shunt surgery can be used to study Alzheimer disease pathology and protein turnover during life. We analysed biopsies from 18 individuals with suspected normal pressure hydrocephalus, alongside matched ventricular and lumbar cerebrospinal fluid and post-mortem control brain tissue. Amyloid plaques were present in 9 of 18 biopsies, while mature tau tangles were rare. Matrix-assisted laser desorption/ionization mass spectrometry imaging mapped amyloid plaque chemistry within tissue. Phosphorylated tau 217 was enriched around plaques, supporting a local relationship between amyloid and tau pathology. Stable isotope labelling, which tracks newly made proteins, detected rapid tau labelling within approximately 3 hours and estimated brain tau half-life at about 34 days. Amyloid plaques showed little detectable turnover.},
  year = {2026},
  journal = {Nature Communications},
  volume = {17},
  pages = {9878},
  month = {2026-09-24},
  issn = {2041-1723},
  url = {https://www.nature.com/articles/s41467-026-76494-4},
  doi = {10.1038/s41467-026-76494-4},
  language = {en},
}