@article{bibcite_8746,
  keywords = {cardiac microtissues, Cardiorenal axis, Drug-induced toxicity, Inter-organ interaction, Kidney organoids},
  author = {Beatrice Gabbin and James Gallant and Fangchen Liu and Hailiang Mei and Berend J. van Meer and Ton J. Rabelink and Christine L. Mummery and Jessica M. Vanslambrouck and Cathelijne W. van den Berg and Viviana Meraviglia and Milena Bellin},
  title = {In vitro modeling of renal injury-induced cardiac effects using human iPSC-derived organoids},
  abstract = {The bidirectional communication between the heart and kidney is essential for physiological homeostasis, with injury in one organ often impairing the other. Although cardiorenal crosstalk is clinically relevant in conditions such as cardiorenal syndrome (CRS), the underlying molecular and cellular mechanisms remain poorly understood, and in vitro models are lacking. Here, we developed a co-culture system using human induced pluripotent stem cell (hiPSC)-derived kidney organoids (kOs) and cardiac microtissues (cMTs) to model the cardiorenal axis.},
  year = {2026},
  journal = {Cell Communication and Signaling},
  volume = {24},
  pages = {380},
  month = {2026-05-06},
  issn = {1478-811X},
  url = {https://doi.org/10.1186/s12964-026-02902-3},
  doi = {10.1186/s12964-026-02902-3},
  language = {en},
}