@article{bibcite_7891, keywords = {cell culture, evidence-based toxicology, risk of bias, user testing}, author = {Gro H. Mathisen and Gunn E. Vist and Paul Whaley and Richard A. White and Trine Hus{\o}y and Heather M. Ames and Anna Beronius and Emma Di Consiglio and Ingrid Druwe and Thomas Hartung and Sebastian Hoffmann and Carlijn R. Hooijmans and Kyriaki Machera and Pilar Prieto and Joshua F. Robinson and Erwin Roggen and Andrew A. Rooney and Nicolas Roth and Eliana Spilioti and Anastasia Spyropoulou and Olga Tcheremenskaia and Emanuela Testai and Mathieu Vinken and Camilla Svendsen}, title = {Protocol: Testing the Performance of INVITES-IN, A Tool for Assessing the Internal Validity of In Vitro Studies}, abstract = {A tool for evaluation of internal validity of in vitro studies called INVITES-IN is currently under development. The tool is designed specifically for cell culture studies. This protocol describes the testing of the performance of INVITES-IN. By performance, we mean the extent to which results of using INVITES-IN are the same for different users (consistency), the amount of time and cognitive effort it takes to apply INVITES-IN (assessor workload), the precision and potential for systematic error in results of applying INVITES-IN (accuracy), and how easy it is to use INVITES-IN (user experience). The participants in the user testing will be representative for the expected end-users of INVITES-IN which are persons preparing literature reviews including in vitro studies (e.g. in the context of chemical hazard and risk assessments or drug development). All end-users are expected to have experience with in vitro methods. Data collected from the performance testing will be used for further refinement and development of the release version of INVITES-IN.}, year = {2023}, journal = {Evidence-Based Toxicology}, volume = {1}, pages = {2293289}, month = {2023-12-31}, issn = {null}, url = {https://doi.org/10.1080/2833373X.2023.2293289}, doi = {10.1080/2833373X.2023.2293289}, }