@article{bibcite_7731,
  keywords = {3D culture, cell culture, Differentiation, Embryonic stem cells, induced pluripotent stem cells, microfluidics, organ-on-a-chip},
  author = {Alexa Wnorowski and Huaxiao Yang and Joseph C. Wu},
  title = {Progress, obstacles, and limitations in the use of stem cells in organ-on-a-chip models},
  abstract = {In recent years, drug development costs have soared, primarily due to the failure of preclinical animal and cell culture models, which do not directly translate to human physiology. Organ-on-a-chip (OOC) is a burgeoning technology with the potential to revolutionize disease modeling, drug discovery, and toxicology research by strengthening the relevance of culture-based models while reducing costly animal studies. Although OOC models can incorporate a variety of tissue sources, the most robust and relevant OOC models going forward will include stem cells. In this review, we will highlight the benefits of stem cells as a tissue source while considering current limitations to their complete and effective implementation into OOC models.},
  year = {2019},
  journal = {Advanced Drug Delivery Reviews},
  volume = {140},
  pages = {3-11},
  month = {2019-02-01},
  issn = {0169-409X},
  url = {https://www.sciencedirect.com/science/article/pii/S0169409X18301327},
  doi = {10.1016/j.addr.2018.06.001},
}