@article{bibcite_7486, keywords = {Computational biology and bioinformatics, Engineering}, author = {Rashmi Pandey and Jennifer Lee and Anahita Mojiri and John P. Cooke and Abhishek Jain}, title = {Time and architecture: the next two dimensions of microphysiological systems}, abstract = {Microphysiological models recapitulating complex vasculature have enabled in vitro evaluation of intricate cellular crosstalk and microenvironmental mechanical cues and stressors. Here, we present a comprehensive review of time and architecture as two under-explored facets required for physiological mimetic vascular models. We conclude with our perspective that incorporating longevity and architecture will improve complex vascular modeling and provide a platform to support chronic disease modeling, personalized medicine, drug testing, and tissue engineering.}, year = {2026}, journal = {npj Biomedical Innovations}, volume = {3}, pages = {22}, month = {2026-03-25}, issn = {3005-1444}, url = {https://www.nature.com/articles/s44385-026-00077-7}, doi = {10.1038/s44385-026-00077-7}, language = {en}, }