@article{bibcite_7281,
  author = {ISoOR Insight Team},
  title = {NIH Shift Away from Animal-Only Research Signals a Major Opportunity for Organoids},
  abstract = {In April 2025, the U.S. National Institutes of Health (NIH) announced a landmark shift that will reshape biomedical ~research for decades: the agency will no longer issue Notices of Funding Opportunities (NOFOs) that rely exclusively on ~animal models. Instead, all future funding calls must include{\textemdash}or explicitly permit{\textemdash}the use of non-animal methods ~(NAMs), including organoids, microphysiological systems, computational models, human-derived tissues, and ~advanced in vitro approaches. This policy, formalized at the first FDA{\textendash}NIH {\textquotedblleft}Workshop on Reducing Animal Testing{\textquotedblright} on ~July 7, 2025, marks an unprecedented reorientation of federal funding priorities toward human-relevant, ethical, and ~translationally predictive model systems. For the organoid field, the implications are vast: expanded funding, ~accelerated standardization, infrastructure scaling, enhanced regulatory relevance, and deeper integration into drug ~development and precision medicine. Yet the shift also presents scientific and practical challenges, including issues of ~reproducibility, biological complexity, and global regulatory acceptance. This article analyzes the motivations behind ~the NIH decision, its transformative significance for organoid science, the challenges ahead, and the role of standards ~such as ISoOR-ISOB and the newly funded Standardized Organoid Modeling (SOM) Center in shaping the next era of ~biomedical research.},
  year = {2025},
  journal = {Journal of Organoid and Bioscience},
  volume = {3},
  month = {2025},
  issn = {3029-2271},
  url = {https://jobs.isoor.org/index.php/journal/article/view/61},
  language = {en},
}