@article{6711,
  keywords = {Capillary Malformation, Endothelial Cells, human induced pluripotent stem cells, Smooth Muscle Cells, Vascular Organoid},
  author = {Vi Nguyen and Anna Harper and Mackenzie Azuero and Isabella Castellanos and Siwuxie He and Marcelo L. Hochman and Camilla F. Wenceslau and Dong-bao Chen and Anil G. Jegga and Yunguan Wang and Daping Fan and J. Stuart Nelson and Wenbin Tan},
  title = {Vascular Organoids Derived from Capillary malformation-induced Pluripotent Stem Cells Exhibit Disease-Relevant Phenotypes},
  abstract = {Capillary malformation (CM) is a congenital vascular anomaly that affects the skin, mucosa, eye, and brain. A major obstacle to mechanistic and drug screening studies for CM has been the lack of preclinical models. In this study, we established vascular organoids (VOs) generated through the self-assembly of vascular lineages of endothelial cells and smooth muscle cells differentiated from CM-induced pluripotent stem cells (iPSC). Within these VOs induced endothelial cells and smooth muscle cells organized into juxtapositions to form vascular branches. CM patient iPSC-derived VOs showed a higher density of endothelial and smooth muscle cell populations and greater vascular branch lengths as compared with VOs derived from iPSCs generated from healthy skin biopsies. Overall, this study represents the first disease-relevant VO model of CM, providing a valuable platform for future mechanistic studies and drug screening.},
  year = {2025},
  journal = {Stem Cell Reviews and Reports},
  month = {2025-09-25},
  issn = {2629-3277},
  url = {https://doi.org/10.1007/s12015-025-10984-8},
  doi = {10.1007/s12015-025-10984-8},
  language = {en},
}