@article{6426,
  keywords = {Analytical biochemistry, Biological models, Biomarkers, Complexity, Stem-cell biotechnology},
  author = {InWha Park and Hyokyeong Gwon and Yeonjeong Jung and Boyoung Kim and Gaeun Ju and Eugene Sin and Hye In An and Hye Jung Bang and Taegwan Yun and Seung Hwan Lee and Wonsik Lee and Choon-Gon Jang and Hyo-Jong Lee and Chung Sub Kim and Jeongmi Lee and Soah Lee},
  title = {Integrating allostasis and emerging technologies to study complex diseases},
  abstract = {The study of complex diseases has traditionally relied on reductionist methods, which, although informative, tend to overlook the dynamic interactions and systemic interconnectivity inherent in biological systems. Allostasis, a framework that focuses on physiological adaptations to stress and the maintenance of stability through change, provides a valuable perspective for understanding these diseases. This review summarizes how the allostasis framework defines the cumulative physiological burden—known as allostatic load—imposed by chronic stressors such as persistent psychosocial pressure, drug abuse, and chronic infections. It also explores how adaptive physiological shifts, or changes in allostatic state, contribute to disorders, particularly drug addiction, immune diseases, and cancer. We then review recent studies that uncover stress adaptation mechanisms using cutting-edge technologies, such as multi-omics approaches, induced pluripotent stem cells (iPSCs), and organoid technology. This integrative approach, combining advanced technologies with the allostasis framework, can deepen our understanding of complex disease pathogenesis and inform the development of more effective diagnostic and therapeutic strategies.},
  year = {2025},
  journal = {Communications Biology},
  volume = {8},
  pages = {1526},
  month = {2025-11-05},
  issn = {2399-3642},
  url = {https://www.nature.com/articles/s42003-025-08939-3},
  doi = {10.1038/s42003-025-08939-3},
  language = {en},
}